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mTOR inhibitor-8

CAS No. : 2489196-70-3

MCE 站：mTOR inhibitor-8

产品活性：mTOR inhibitor-8 是一种 mTOR 抑制剂和自噬 (autophagy) 诱导剂。mTOR inhibitor-8 通过 FKBP12 抑制 mTOR 活性，并诱导 A549 人肺癌细胞自噬。

研究领域：PI3K/Akt/mTOR  |  Autophagy

作用靶点：mTOR  |  Autophagy

In Vitro: mTOR inhibitor-8 (Compound 5e; 0.1-10?μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner.
mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10?μM; 3-24?hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced.
mTOR inhibitor-8 (10?μM; 3-24?hours) reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR

In Vivo: mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Differentiation Inducing Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Rapamycin  |  Everolimus  |  MHY1485  |  3BDO  |  Temsirolimus  |  Salidroside  |  Torkinib  |  PI-103  |  D-α-Hydroxyglutaric acid disodium  |  L-Leucine  |  Dihydromyricetin  |  PKI-402  |  Polyphyllin I  |  Rheb inhibitor NR1  |  GSK1059615  |  GNE-317  |  PP121  |  WYE-354  |  Cyclovirobuxine D  |  HDACs/mTOR Inhibitor 1  |  XL388  |  ETP-46464  |  Palomid 529  |  WAY-600  |  Arnicolide D  |  (+)-Usnic acid  |  hSMG-1 inhibitor 11j  |  mTOR inhibitor-1  |  TMBIM6 antagonist-1  |  Hederacolchiside A1

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