MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AP39

CAS No. : 1429061-80-2

MCE 站：AP39

产品活性：AP39 是三苯基膦衍生的茴香脑二硫代硫酮和靶向线粒体的硫化氢 (H₂S) 供体。AP39 在氧化应激条件下发挥细胞保护作用并保持线粒体 DNA 完整性。AP39 增加细胞内 H₂S 水平。AP39 可以防止小鼠模型中心肌再灌注损伤，有潜力用于阿尔茨海默氏病的研究。

研究领域：Others

作用靶点：Others

In Vitro: AP39 (25,100?nM; for 24?h) results in increase in cell viability in APP/PS1 neurons and has no effect on cell viability in WT neurons.
AP39 (100?nM) increases the levels of OPA1 and Mfn1 but not Mfn2. Moreover, AP39 decreases the levels of Fis1 but not Drp1.
AP39 (25-250?nM; 2 h) induces a concentration-dependent increase in H₂S generation and in the fluorescence of the H₂S-detecting dye AzMC.
AP39 (100?nM) significantly increases the basal respiratory rate and the OCR-linked maximal respiratory capacity of the APP/PS1 neurons. AP39 significantly increases the ATP production in WT and APP/PS1 neurons. AP39 significantly protects against mtDNA damage in APP/PS1 neurons by partially restoring mtDNA integrity.
AP39 consists of a mitochondria-targeting motif, triphenylphosphonium (TPP⁺), coupled to a H₂S-donating moiety (dithiolethione) by an aliphatic linker.AP39 (100 nM) reduces intracellular oxidative stress and in the meantime it consequently sustaines the cell viability, mitochondrial respiration and mitochondrial DNA integrity. These effects tend to be stimulatory at lower concentrations (30 and 100 nM), but tend to diminish or convert into inhibitory effects at a higher concentration (300 nM).

In Vivo: AP39 (100?nM/kg/day; ip; for 6 weeks) ameliorates the learning and memory deficits of APP/PS1 mice. AP39 (25-250?nM/kg/day; ip; for 6 weeks) induces a dose-dependent increase in H₂S generation in the cortex and hippocampus of WT and APP/PS1 mice.
AP39 (0.01, 0.1, 1 μmol/kg; iv; bolus 10 min before reperfusion) dose‐dependently reduces infarct size anaesthetized by thiobutabarbital (200 mg/kg, i.p) in male Sprague Dawley rats, 300-350 g (9-11 weeks).

相关产品：Bioactive Compound Library Plus  |  Anti-Aging Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Anti-Alzheimer’s Disease Compound Library  |  PEG300  |  SBE-β-CD  |  Corn oil  |  Tween 80  |  Polyethylene glycol 12-hydroxystearate  |  JC-1  |  Lipopolysaccharides  |  DTT  |  (2-Hydroxypropyl)-β-cyclodextrin  |  Methyl-β-cyclodextrin  |  CFSE  |  Digitonin  |  D-Luciferin potassium salt  |  Thiazolyl Blue  |  Biotin  |  3X FLAG peptide TFA  |  Monocrotaline  |  Nile Red  |  Auxinole  |  Tocofersolan  |  FLAG peptide  |  IPTG  |  Yoda 1  |  Cremophor EL  |  GsMTx4 TFA  |  Propidium Iodide  |  DAPI dihydrochloride  |  Calcein-AM  |  Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。