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NCT-504

CAS No. : 1222765-97-0

MCE 站：NCT-504

产品活性：NCT-504 是选择性的脂质激酶 PIP4Kγ 变构抑制剂，其 IC₅₀ 值为 15.8 μM。NCT-504 具有用于亨廷顿氏症疾病研究的潜力。

研究领域：Others

作用靶点：Others

In Vitro: NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate.
NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P .
NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC₅₀ between 50 μM and 100 μM) at 50 μM concentration.
NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs.
NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs.
NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo.
NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes.
NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells.
NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice.

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