型号:
产品价格:电议      采购度:1601      原产地:美洲
发布时间:2021/7/27 12:30:06 所属地区:上海 上海市
简要描述:
PKF050-638 是一种有效且具有选择性的 HIV-1 Rev 抑制剂 (IC50= μM)。 PKF050-638 通过破坏 CRM1-NES 相互作用抑制 CRM1 介导的 Rev 核输出。
标签:pkf050
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CAS No. : 528893-52-9
MCE 站:PKF050-638
产品活性:PKF050-638 是一种有效且具有选择性的 HIV-1 Rev 抑制剂 (IC50=0.04 μM)。 PKF050-638 通过破坏 CRM1-NES 相互作用抑制 CRM1 介导的 Rev 核输出。
研究领域:Anti-infection | Membrane Transporter/Ion Channel
In Vitro: Nuclear export of Rev is mediated by its leucine-rich nuclear export signal (NES) and is known to use the CRM1 export factor to export the viral RNA from the nucleus to the cytoplasm. CRM1 is a nuclear export receptor for proteins carrying the leucine-rich NES.PKF050-638 (5 μM; 2 hours) inhibits nuclear export of rev, in addition, the Rev14-GFP mutant accumulates in the nucleus indicating that the NES of Rev is a part of Rev required for export inhibition by PKF050-638.PKF050-638 (7.5 μM; 4 hours) restores the inhibition of export in pRev14-GFP-transfected cells. In cells incubated with PKF050-638, most of the Rev14-GFP is localized in the nucleus and nucleolus. Whereas in untreated cells, Rev14-GFP is still in the cytoplasm. This result shows that the majority of PKF050-638-treated cells are able to reverse completely the inhibitory effects of the agent.PKF050-638 (7.5 μM; 1 hour) is interfering with the CRM1-mediated nuclear export machinery. HeLa cells are cotransfected with the BFP-tagged Rev protein and the GFP-tagged hCRM1. Upon treatment with PKF050-638, this Rev-dependent hCRM1 nucleolar localization is abolished after 60 min, and PKF050-638 does not affect the Rev nucleolar distribution.
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更新时间:2024/1/2 10:16:38
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