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BML-284 hydrochloride

CAS No. : 2095432-75-8

MCE 站：BML-284 hydrochloride

产品活性：BML-284 hydrochloride 是一种有效的细胞通透性 Wnt 信号激活剂。BML-284 hydrochloride 诱导 TCF 依赖的转录活性，其 EC₅₀>700 nM 。

研究领域：Stem Cell/Wnt

作用靶点：Wnt

In Vitro: BML-284 (10 ?M; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.
BML-284 (10 ?M; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.

In Vivo: BML-284 hydrochloride (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.

相关产品：CHIR-99021  |  IWR-1  |  IWP-2  |  Pyrvinium pamoate  |  Salinomycin  |  Heparan Sulfate  |  BML-284  |  HLY78  |  FH535  |  Wogonin  |  Echinacoside  |  PNU-74654  |  Prinaberel  |  Triptonide  |  IWP-4  |  L-Quebrachitol  |  Pamidronic acid  |  SKI II  |  Gigantol  |  Ginkgetin  |  IWP-O1  |  Methyl vanillate  |  Prodigiosin  |  Astragaloside I  |  Specnuezhenide  |  Cardiogenol C hydrochloride  |  Hematein

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