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PD-1/PD-L1-IN 7

CAS No. : 2374856-75-2

MCE 站：PD-1/PD-L1-IN 7

产品活性：PD-1/PD-L1-IN 7 是一种人 PD-1/PD-L1 蛋白/蛋白相互作用的抑制剂，IC₅₀ 为 0.213 nM。PD-1/PD-L1-IN 7 具有抗癌和抗病毒功能。

研究领域：Immunology/Inflammation  |  Anti-infection

作用靶点：PD-1/PD-L1  |  HBV

In Vitro: PD-1/PD-L1-IN 7 (compound 139) enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8⁺ T Cells and CD4⁺ T Cells. PD-1/PD-L1-IN 7 also enhances the frequency of GrB⁺ cells among HBV-specific CD8⁺ and CD4⁺ T cells. The ability of PD-1/PD-L1-IN 7 to enhance the antiviral functions of HBV-specific CD8⁺ and CD4⁺ T cells in vitro is comparable to those of Durvalumab.

In Vivo: PD-1/PD-L1-IN 7 (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. PD-1/PD-L1-IN 7 significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model.

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