MEISi-2

CAS No. : 2250156-71-7

MCE 站：MEISi-2

产品活性：MEISi-2 是一种选择性的 MEIS 抑制剂，MEIS 是造血干细胞 (HSC) 自我更新的关键调控因子。MEISi-2 被开发用于心脏损伤、造血问题、骨髓移植和癌症的研究。

研究领域：Others

作用靶点：Others

In Vitro: MEISi-2 does not significantly inhibit the PBX-Luc-reporter.
MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance ａnd self-renewal.
MEISi-2 down-regulates MEIS target gene expression.
MEISi-2 induces murine (LSKCD34^low cells) ａnd human (CD34⁺, CD133⁺, ａnd ALDH^hi cells) HSC self-renewal ex vivo.

In Vivo: MEISi-2 (10 µM; i.p.; at day 1, day 4 ａnd day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34^low HSC content ａnd LSKCD150+CD48- HSC content.
MEISi-2 down-regulates Meis1 expression, Hif-2α, ａnd key CDKI gene expression including p16, p19, p19ARF.

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