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Retro-2

CAS No. : 1201652-50-7

MCE 站：Retro-2

产品活性：Retro-2 是一种内体蛋白质-高尔基体逆行运输的选择性抑制剂。Retro-2 是一种埃博拉病毒 (EBOV) 感染抑制剂，在 HeLa 细胞中的EC₅₀ 为 12.2 ?M。Retro-2 还可诱导细胞自噬 (autophagy)。

研究领域：Anti-infection  |  Autophagy

作用靶点：Filovirus  |  Parasite  |  Autophagy

In Vitro: Retro-2 (1 μM; 1-4 hours) induces autophagy in GFP-LC3-expressing HeLa cells and promoted the dramatic cytoplasmic accumulation of large autophagosomes.
Retro-2 (1 μM; 0.5-4 hours) treatment hows an increase over time of the abundance of LC3-II protein in cells.
Retro-2 impairs the trafficking between autophagosomes and lysosomes. Retro-2 abolishes autolysosomes formation.
Retro-2 (20 μM; pretreatment for 30 min) inhibits HeLa cell intoxication by ricin, Shiga-like toxins 1 (Stx1) and 2 (Stx2).
Retro-2 blocked invasion of cells by the intracellular parasite Leishmania, as well as replication of non-enveloped viruses, including polyoma-, papilloma-, and adeno-associated viruses.

In Vivo: Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Chloroquine  |  Hydroxychloroquine sulfate  |  Ivermectin  |  Kaempferol  |  Metronidazole  |  Dihydroartemisinin  |  Niclosamide  |  Suramin sodium salt  |  Artesunate  |  Artemisinin  |  Quinidine  |  Halofuginone  |  Miransertib  |  Galidesivir hydrochloride  |  Mefloquine hydrochloride  |  Quinacrine dihydrochloride  |  Sanguinarine chloride  |  Amodiaquine dihydrochloride dihydrate  |  Ascomycin  |  Mebendazole  |  Atovaquone  |  Methylene Blue  |  Bithionol  |  Diminazene aceturate  |  Okadaic acid  |  Quinine  |  Urethane  |  Levamisole hydrochloride

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