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SKF-96365 hydrochloride

CAS No. : 130495-35-1

MCE 站：SKF-96365 hydrochloride

产品活性：SKF-96365 hydrochloride 是一种有效的 TRP channel 阻滞剂和 SOCE (store-operated Ca²⁺ entry) 抑制剂。SKF-96365 hydrochloride 可显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流，显著延长 QTc 间期。SKF-96365 hydrochloride 通过诱导结直肠癌细胞的细胞周期阻滞和凋亡 (apoptosis) 而显示出强大的抗肿瘤活性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Autophagy  |  Apoptosis

作用靶点：TRP Channel  |  CRAC Channel  |  Potassium Channel  |  Autophagy  |  Apoptosis

In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects.

In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  Acetylcysteine  |  Angiotensin II human  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Bortezomib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Verteporfin  |  Decitabine  |  Actinomycin D  |  Temozolomide  |  BAY 11-7082  |  Etoposide  |  Mitomycin C  |  CCCP  |  DAPT  |  Nigericin sodium salt  |  Rotenone  |  Etomoxir  |  Stattic  |  Docetaxel

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