MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Metipranolol

CAS No. : 22664-55-7

MCE 站：Metipranolol

产品活性：Metipranolol 是一种非选择性的具有口服活性的 β-肾上腺素能受体 (β-adrenergic receptor) 拮抗剂。Metipranolol 可用于高血压和青光眼的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: In vitro β1- and β2-adrenoceptor antagonism is evaluated using the guinea pig atrium and the rat uterus, respectively. The respective pA₂ values are 8.3 and 8.4.
Metipranolol significantly reduces iron/ascorbate-induced lipid peroxidation in rat brain homogenates with an IC₅₀ value of 6.9 μM . Metipranolol also concentration-dependently inhibits sodium nitroprusside-stimulated lipid peroxidation in rat brain homogenates, displaying an IC₅₀ value of 25.1 μM.

In Vivo: At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Ferroptosis Compound Library  |  Neurotransmitter Receptor Compound Library  |  Isoprenaline hydrochloride  |  ICI 118,551 hydrochloride  |  Propranolol hydrochloride  |  Norepinephrine  |  Phenylephrine hydrochloride  |  Pimozide  |  Yohimbine Hydrochloride  |  Olanzapine  |  Prazosin hydrochloride  |  Atenolol  |  Carvedilol  |  CL 316243  |  Amitriptyline hydrochloride  |  Dexmedetomidine hydrochloride  |  L-Epinephrine  |  Metoprolol Succinate  |  YS-49  |  Pindolol  |  Dobutamine hydrochloride  |  Nebivolol hydrochloride  |  Salmeterol  |  Labetalol hydrochloride  |  Perphenazine  |  (S)-Timolol Maleate  |  (±)-Bisoprolol hemifumarate  |  Phentolamine mesylate  |  Terazosin hydrochloride dihydrate  |  Ivabradine hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。