型号:
产品价格:电议      采购度:1600      原产地:美洲
发布时间:2021/7/28 17:39:37 所属地区:上海 上海市
简要描述:
Ro 363 hydrochloride,一种有效的正性肌力活化剂,是一种有效且高度选择性的 β1 肾上腺素受体 (β1-adrenoceptor) 激动剂。Ro 363 hydrochloride 是一种心血管调节剂,可降低舒张压并显着增加心肌收缩力。
标签:ro-363
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CAS No. : 250580-70-2
MCE 站:Ro 363 hydrochloride
产品活性:Ro 363 hydrochloride,一种有效的正性肌力活化剂,是一种有效且高度选择性的 β1 肾上腺素受体 (β1-adrenoceptor) 激动剂。Ro 363 hydrochloride 是一种心血管调节剂,可降低舒张压并显着增加心肌收缩力。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Adrenergic Receptor
In Vitro: Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses.
In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations.
In Vivo: In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane.
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更新时间:2024/1/2 10:16:51
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