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Nur77 modulator 1

CAS No. : 2469975-55-9

MCE 站：Nur77 modulator 1

产品活性：Nur77 modulator 1 可结合到Nur77 (K_D = 3.58 μM)。Nur77 modulator 1 上调 Nur77 表达，介导Nur77亚细胞定位，诱导Nur77 依赖的内质网应激和自噬，可导致细胞凋亡。抗肝癌生物活性。

研究领域：Others

作用靶点：Others

In Vitro: Nur77 modulator 1 (10g, 0-20 μM) displays potent and broad-spectrum antiproliferative activity against all tested three hepatoma cell lines (HepG2, QGY-7703, and SMMC-7721), and less cytotoxicity against LO2 cells (human normal liver cell line).
Nur77 modulator 1 (10g, ) could specifically up-regulate the expression of Nur77 in a dose-dependent manner.
Nur77 modulator 1 (10g, 2.0 μM) induces Nur77-dependent apoptosis.
Nur77 modulator 1 (10g, 2.0 μM) increased LC3-II and Beclin1 protein levels in a dose-dependent manner (10g treatment does not enhance p62 degradation, indicating that autophagy induced by 10g is incomplete).

In Vivo: Nur77 modulator 1 (10g, 10 and 20 mg/kg/day) exhibits significant anti-tumor activity in mouse hepatoma HepG2 xenograft with good tolerability.

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