MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

CAS No. : 132465-11-3

MCE 站：Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

产品活性：Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) 是一种有效的 12/15 脂氧合酶 (12/15-LO) 抑制剂。Cinnamyl-3,4-dihydroxy-α-cyanocinnamate 可用于研究1型糖尿病。

研究领域：Metabolic Enzyme/Protease

作用靶点：Lipoxygenase

In Vitro: High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport.

In Vivo: The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Diabetes Related Compound Library  |  Ferroptosis Compound Library  |  U-73122  |  Zileuton  |  Wedelolactone  |  Nordihydroguaiaretic acid  |  Caffeic acid  |  Indirubin-3'-monoxime  |  Chebulagic acid  |  Docebenone  |  Licofelone  |  Pectolinarigenin  |  Psoralidin  |  Lonapalene  |  S-(+)-Marmesin  |  Xanthatin  |  4-MMPB  |  5-O-Demethylnobiletin  |  11-?Keto-?beta-?boswellic acid  |  2,5-Di-tert-butylhydroquinone  |  4',5-Dihydroxyflavone  |  Enazadrem  |  FPL 62064  |  Malotilate  |  PF-4191834  |  PGS-IN-1  |  Phenidone  |  β-Boswellic acid  |  3-O-Acetyl-11-hydroxy-beta-boswellic acid  |  Atreleuton  |  LY 178002

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。