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Bay K 8644

CAS No. : 71145-03-4

MCE 站：Bay K 8644

产品活性：Bay K 8644，一种二氢吡啶化合物，是一种特定的 L 型 Ca²⁺ 通道激动剂。Bay K 8644 通过增加通道的开放时间来增加通过肌膜 Ca²⁺ 通道的 Ca²⁺ 流入。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development.

In Vivo: A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats.

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