MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Chlorambucil

CAS No. : 305-03-3

MCE 站：Chlorambucil

产品活性：Chlorambucil 是一种口服抗肿瘤活性剂和双功能烷基化剂 (alkylating agent)，属于氮芥类。Chlorambucil 可用于研究淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病。

研究领域：Cell Cycle/DNA Damage

作用靶点：DNA Alkylator/Crosslinker

In Vitro: Chlorambucil can deprive the function of complementary strands of DNA molecules via alkalization-induced cross interaction, and then inhibits tumor cell proliferation. Chlorambucil (0, 2.5, 5, 10 μM) exhibits slight inhibitory effect on Raji cell apoptosis, but potently increases DR4 and DR5 mRNA expression in Raji cells. Chlorambucil (10 μM) in combination with Tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL, 80 ng/ml) has synergistic effect on Raji cell apoptosis and inhibition on proliferation.
Chlorambucil is a DNA alkylator at high doses and, at lower doses, acts as an inhibitor of synthesis of nuclear proteins, particularly histones. Increasing doses are associated with a higher frequency of apoptosis, whereas long-term maintenance therapy has been associated with mutations of the p53 gene, leading to secondary malignancies.

In Vivo: Chlorambucil (0.2 mg/kg, p.o.) in combination with levamisole (5 mg/kg) has enhanced anti-cancer effect on Ehrlich ascites carcinoma which elevates apoptosis of Ehrlich ascites carcinoma and the survival rate of the mice. However, Chlorambucil exhibits adverse effects on the liver and kidneys of mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Blood Cancer Compound Library  |  Cisplatin  |  Oxaliplatin  |  Temozolomide  |  Mitomycin C  |  Carboplatin  |  Cyclophosphamide  |  Streptozocin  |  N-Nitroso-N-methylurea  |  Busulfan  |  Calicheamicin  |  Ifosfamide  |  Melphalan  |  Bendamustine hydrochloride  |  RITA  |  Carmustine  |  Lomustine  |  Thio-TEPA  |  Altretamine  |  4-Hydroperoxy cyclophosphamide  |  Duocarmycin TM  |  Procarbazine Hydrochloride  |  Phosphoramide mustard (cyclohexanamine)  |  SJG-136  |  VAL-083  |  Trioxsalen  |  Palifosfamide  |  Treosulfan  |  Miriplatin  |  Nimustine hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。