MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PTP1B-IN-3 diammonium

CAS No. :

MCE 站：PTP1B-IN-3 diammonium

产品活性：PTP1B-IN-3 diammonium 是有效的，有选择性的 PTP1B 抑制剂，对 PTP1B 和 TCPTP 的 IC₅₀ 值均为 120 nM。PTP1B-IN-3 diammonium 具有抗糖尿病和抗癌作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vivo: In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits dose dependent inhibition (60%, 80% and 100% inhibition at 1, 3 and 10 mg/kg, respectively) of glucose excursion when given orally 2 h before oral glucose challenge with an estimated ED₅₀ of 0.8 mg/kg.
In the NDL2 Ptpn1 transgenic mice, PTP1B-IN-3 (compounds 3g; orally; 30 mg/kg for 21 days) shows a significant delay in the onset of tumor development in NDL2 Ptpn1^+/+ mice, extending the median tumor free days (T50) from 28 days to 75 days.
In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits good oral bioavailability (F of 24%), slow clearance (CL of 0.71 mL/kg/min), and good elimination half live (t_1/2 of 6 h). The oral bioavailability in higher species such as rats (F of 4%) and squirrel monkeys (F of 2%) are substantially lower but excellent exposures are achieved with oral dosing.

相关产品：Cyclosporin A  |  Tacrolimus  |  Ebselen  |  Salubrinal  |  Suramin sodium salt  |  Calyculin A  |  β-Glycerophosphate disodium salt pentahydrate  |  Sodium orthovanadate  |  TPI-1  |  MSI-1436 lactate  |  GSK 2830371  |  NSC 663284  |  Okadaic acid  |  D-erythro-Sphingosine  |  SF1670  |  Sodium metatungstate  |  BCI  |  Sodium stibogluconate  |  Voclosporin  |  MB05032  |  Pentamidine isethionate  |  3α-Aminocholestane  |  ARL67156 trisodium salt  |  BVT948  |  PTP1B-IN-2  |  KY-226  |  GNF362  |  L-690330

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。