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AK-7

CAS No. : 420831-40-9

MCE 站：AK-7

产品活性：AK-7 是一种可透过细胞及血脑屏障的 SIRT2 抑制剂，IC₅₀ 值为 15.5 μM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Sirtuin

In Vitro: AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures.

In Vivo: AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  Resveratrol  |  Selisistat  |  Nicotinamide  |  Nicotinamide riboside chloride  |  3-TYP  |  Suramin sodium salt  |  OSS_128167  |  Fisetin  |  UBCS039  |  Sirtinol  |  CAY10602  |  AGK2  |  SIRT5 inhibitor 1  |  Cambinol  |  MC3482  |  Ganoderic acid D  |  PROTAC Sirt2 Degrader-1  |  SRT 2183  |  Dihydrocoumarin  |  Ginkgolide C  |  Inauhzin  |  SIRT-IN-3  |  JFD00244  |  Gardenia yellow  |  Agrimol B  |  Sirtuin modulator 1  |  Ophiopogonin D'  |  Scopolin  |  SirReal2

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