MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

H-89

CAS No. : 127243-85-0

MCE 站：H-89

产品活性：H-89 是一种有效、选择性的 cAMP 依赖性 protein kinase A 抑制剂，IC₅₀ 值为 48 nM，对 PKG，PKC，Casein Kinase 和其他激酶的抑制作用很弱。

研究领域：Protein Tyrosine Kinase/RTK  |  Stem Cell/Wnt  |  Autophagy

作用靶点：PKA  |  Autophagy

In Vitro: H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca²⁺ uptake by the SR and affectes the Ca³²-sensitivity of the contractile apparatus in rat skinned fibres.

In Vivo: H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.

相关产品：Staurosporine  |  H-89 dihydrochloride  |  Bucladesine sodium  |  8-Bromo-cAMP sodium salt  |  Fasudil Hydrochloride  |  K-252a  |  Metadoxine  |  Daphnetin  |  HA-100  |  KT5720  |  Gliotoxin  |  PKA Inhibitor Fragment (6-22) amide TFA  |  KT5823  |  PKI(5-24)  |  AT7867 dihydrochloride  |  Kemptide  |  PKI 14-22 amide,myristoylated TFA  |  Rp-cAMPS triethylammonium salt  |  Sp-cAMPS  |  A-3 hydrochloride  |  Bilobetin  |  Jaspamycin  |  Malantide  |  UCN-02  |  Warangalone

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。