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H-89 dihydrochloride

CAS No. : 130964-39-5

MCE 站：H-89 dihydrochloride

产品活性：H-89 dihydrochloride 是一种有效、选择性的 cAMP 依赖性蛋白激酶A (PKA) 抑制剂，IC₅₀ 值为 48 nM。也可轻微抑制 PKG，PKC，酪蛋白激酶活性。

研究领域：Protein Tyrosine Kinase/RTK  |  Stem Cell/Wnt  |  Autophagy

作用靶点：PKA  |  Autophagy

In Vitro: H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca²⁺ uptake by the SR and affectes the Ca²⁺-sensitivity of the contractile apparatus in rat skinned fibres.

In Vivo: H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Stem Cell Signaling Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Staurosporine  |  Bucladesine sodium  |  8-Bromo-cAMP sodium salt  |  Fasudil Hydrochloride  |  K-252a  |  Metadoxine  |  Daphnetin  |  HA-100  |  KT5720  |  Gliotoxin  |  PKA Inhibitor Fragment (6-22) amide TFA  |  KT5823  |  PKI(5-24)  |  AT7867 dihydrochloride  |  Kemptide  |  PKI 14-22 amide,myristoylated TFA  |  Rp-cAMPS triethylammonium salt  |  Sp-cAMPS  |  A-3 hydrochloride  |  Bilobetin  |  H-89  |  Jaspamycin  |  Malantide  |  UCN-02  |  Warangalone

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