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Atipamezole hydrochloride

CAS No. : 104075-48-1

MCE 站：Atipamezole hydrochloride

产品活性：Atipamezole (MPV-1248) hydrochloride 是一种 α2-肾上腺素受体拮抗剂, K_i 值为 1.6 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: The affinity of atipamezole for α₂-adrenoceptors and its α₂/α₁ selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α₂-adrenoceptors. It has negligible affinity for 5-HT₁, 5-HT2 and I2 bindings sites.

In Vivo: Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory.

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