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Z-DEVD-FMK

CAS No. : 210344-95-9

MCE 站：Z-DEVD-FMK

产品活性：Z-DEVD-FMK 是一种特异性的不可逆的 caspase-3 抑制剂，IC₅₀ 为 18 μM。

研究领域：Apoptosis

作用靶点：Caspase

In Vitro: N27 cells are exposed to MPP⁺ in the absence or presence of 50 μM Z-DIPD-FMK or 100 μM Z-DEVD-FMK or 50 μM Z-LEHD-FMK and then caspase-9 and caspase-3 enzymatic activities are determined by enzymatic assay at 12 and 24 h following exposure, respectively. Exposure to 300 μM MPP⁺ for 24 h in N27 cells results in an approximately 2.5-fold increase in caspase-3 enzyme activity. MPP⁺-induced increases in caspase-3 enzyme activity are significantly blocked by 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, and 50 μM Z-LEHD-FMK.

In Vivo: Early Z-DEVD-FMK (160 ng) treatment improves motor and cognitive function after traumatic CNS injury induced by severe controlled cortical impact (CCI) in the mouse. Treatment with Z-DEVD-FMK (160 ng) significantly improves neurological outcome when compared with traumatized animals treated with DMSO vehicle (p<0.01).

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Anti-Cancer Compound Library  |  Peptidomimetic Library  |  Covalent Screening Library  |  Pyroptosis Compound Library  |  Z-VAD(OMe)-FMK  |  Z-IETD-FMK  |  Tauroursodeoxycholate Sodium  |  Emricasan  |  Ac-DEVD-CHO  |  Guggulsterone  |  Wedelolactone  |  Z-YVAD-FMK  |  Ginsenoside Rh2  |  Terfenadine  |  Dehydrocorydaline chloride  |  Crustecdysone  |  Phenoxodiol  |  Ac-FLTD-CMK  |  Asperosaponin VI  |  BOC-D-FMK  |  Taurodeoxycholic acid sodium hydrate  |  2-HBA  |  Fenbufen  |  Arnicolide D  |  Z-WEHD-FMK  |  ZYZ-488  |  5,?7,?4'-?Trimethoxyflavone  |  Chelidonic acid  |  Paris saponin VII  |  Aristolactam I

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