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Amikacin disulfate

CAS No. : 39831-55-5

MCE 站：Amikacin disulfate

产品活性：Amikacin disulfate (BAY 41-6551 disulfate) 是一种氨基糖苷类抗生素，也是一种卡那霉素的半合成类似物。Amikacin disulfate 具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。Amikacin disulfate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin disulfate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD₅₀ value of 453 μM.

In Vivo: Amikacin (320?mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.

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