MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

(S)-(-)-Bay-K-8644

CAS No. : 98625-26-4

MCE 站：(S)-(-)-Bay-K-8644

产品活性：(S)-(-)-Bay-K-8644 是 L 型钙离子通道激动剂。(S)-(-)-Bay-K-8644 激活 Ba²⁺电流 (I_Ba)，EC₅₀ 为 32 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca²⁺ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I_Ba in gastric myocytes of the guinea pig antrum. The Ca²⁺ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca²⁺ channels. The interactions of two Ca²⁺ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca²⁺ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC₅₀=14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca²⁺ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Reprogramming Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Ionomycin  |  L-Ascorbic acid  |  Thapsigargin  |  Verapamil hydrochloride  |  Ebselen  |  Nifedipine  |  Fasudil Hydrochloride  |  2-Aminoethyl diphenylborinate  |  Acetylcholine chloride  |  GSK1016790A  |  Tetrandrine  |  Mibefradil dihydrochloride  |  CDN1163  |  Nimodipine  |  Gabapentin  |  L-Phenylalanine  |  Penfluridol  |  Diltiazem hydrochloride  |  Istaroxime hydrochloride  |  Cromolyn sodium  |  GSK-7975A  |  Ethacrynic acid  |  Felodipine  |  Cilnidipine  |  Amlodipine  |  Ru360  |  DS16570511  |  Ranolazine dihydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。