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Nicardipine hydrochloride

CAS No. : 54527-84-3

MCE 站：Nicardipine hydrochloride

产品活性：Nicardipine hydrochloride (YC-93) 是一种钙通道 (calcium channel) 阻滞剂，可阻断心脏钙通道，IC₅₀ 为 1 μM。 Nicardipine hydrochloride 可用于研究慢性心绞痛以及控制血压。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Autophagy

作用靶点：Calcium Channel  |  Autophagy

In Vitro: Nicardipine (0.1-10 μM; 24-48 h) reduces viability and proliferation of vascular smooth muscle cells (VSMCs) and inhibits their ability to migrate.

In Vivo: Nicardipine (0.3-10 mg/kg; p.o.) shows antihypertensive properties.
LD₅₀s of Nicardipine are 643 mg/kg (oral) and 557 mg/kg (oral); 18.1 mg/kg (intravenous) 25.0 mg/kg (intravenous); 735 mg/kg (subcutaneous) and 683 mg/kg (subcutaneous); 171 mg/kg (intraperitoneally) and 155 mg/kg (intraperitoneally) for male and female Sprague-Dawley rats, respectively.
LD₅₀s of Nicardipine are 187 mg/kg (oral) and 15.5 mg/kg (intravenous) for male Wistar rats, respectively.
LD₅₀s of Nicardipine are 634 mg/kg (oral) and 650 mg/kg (oral); 20.7 mg/kg (intravenous) 19.9 mg/kg (intravenous); 540 mg/kg (subcutaneous) and 710 mg/kg (subcutaneous); 144 mg/kg (intraperitoneally) and 161 mg/kg (intraperitoneally) for male and female mice, respectively.

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