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Silmitasertib sodium salt

CAS No. : 1309357-15-0

MCE 站：Silmitasertib sodium salt

产品活性：Silmitasertib sodium salt 是一种有效、可口服、高度选择性的 CK2 抑制剂，对 CK2α 和 CK2α' 的 IC₅₀值均为 1 nM。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Autophagy

作用靶点：Casein Kinase  |  Autophagy

In Vitro: Silmitasertib (CX-4945) causes cell-cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells, attenuates PI3K/Akt signalingand, and the antiproliferative activity of Silmitasertib (CX-4945) is correlated with expression levels of the CK2α catalytic subunit, Attenuation of PI3K/Akt signaling. Silmitasertib (CX-4945) with PS-341 treatment prevents leukemic cells from engaging a functional UPR in order to buffer the PS-341-mediated proteotoxic stress in ER lumen, and decreases pro-survival ER chaperon BIP/Grp78 expression. Silmitasertib (CX-4945) induces cytotoxicity and apoptosis, and exerts anti-proliferative effects in hematological tumors by downregulating CK2 expression and suppressing activation of CK2-mediated PI3K/Akt/mTOR signaling pathways.

In Vivo: Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Orally Active Compound Library  |  LY294002  |  IWP-2  |  Emodin  |  D4476  |  Ellagic acid  |  TBB  |  TAK-715  |  DMAT  |  PF-670462  |  IC261  |  Longdaysin  |  TTP 22  |  PF-4800567  |  CKI-7 free base  |  NCC007  |  AMG-548 dihydrochloride  |  Casein Kinase II Inhibitor IV  |  CK2/ERK8-IN-1  |  Hematein  |  LH846  |  TBCA  |  PI-828  |  A-3 hydrochloride  |  CK2/PIM1-IN-1  |  TMCB

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