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FTI-277

CAS No. : 170006-73-2

MCE 站：FTI-277

产品活性：FTI-277 是法尼基转移酶 FTase 抑制剂，高效 Ras CAAX 肽模拟物，可抑制 H-Ras 和 K-Ras 信号转导。FTI-277 可抑制 hepatitis delta virus (HDV) 感染。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis  |  GPCR/G Protein

作用靶点：Farnesyl Transferase  |  Apoptosis  |  Ras

In Vitro: Treatment with FTI-277 (20 μM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types
. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner.

In Vivo: FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice.

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