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Lidocaine hydrochloride

CAS No. : 73-78-9

MCE 站：Lidocaine hydrochloride

产品活性：Lidocaine (Lignocaine) hydrochloride 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，有局部麻醉活性。Lidocaine hydrochloride 一种研究室性心律失常的药物和有效的肿瘤抑制剂。

研究领域：Membrane Transporter/Ion Channel  |  MAPK/ERK Pathway  |  Stem Cell/Wnt  |  NF-κB  |  Apoptosis

作用靶点：Sodium Channel  |  MEK  |  ERK  |  NF-κB  |  Apoptosis

In Vitro: Lidocaine hydrochloride (Lignocaine hydrochloride) (10 nM; 48 hours) decreases significantly cell proliferation.
Lidocaine hydrochloride (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10?nM and treatment time 48?hours.
Lidocaine hydrochloride (10 nM; 48 hours) increases significantly the apoptotic cell rate.
Lidocaine hydrochloride (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.

In Vivo: Lidocaine hydrochloride (Lignocaine hydrochloride) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.

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