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MHY1485

CAS No. : 326914-06-1

MCE 站：MHY1485

产品活性：MHY1485 是一种有效的细胞渗透性 mTOR 激活剂，靶向 mTOR 的 ATP 结构域。MHY 1485 通过抑制自噬体和溶酶体之间的融合来抑制自噬 (autophagy)。

研究领域：PI3K/Akt/mTOR  |  Autophagy

作用靶点：mTOR  |  Autophagy

In Vitro: MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells.
MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells.
MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells.

In Vivo: MHY1485 (intraperitoneal injection; 10?mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH). It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Rapamycin  |  Everolimus  |  3BDO  |  Temsirolimus  |  Salidroside  |  Torkinib  |  PI-103  |  D-α-Hydroxyglutaric acid disodium  |  L-Leucine  |  Dihydromyricetin  |  PKI-402  |  Polyphyllin I  |  Rheb inhibitor NR1  |  GSK1059615  |  GNE-317  |  PP121  |  WYE-354  |  Cyclovirobuxine D  |  HDACs/mTOR Inhibitor 1  |  XL388  |  ETP-46464  |  Palomid 529  |  WAY-600  |  Arnicolide D  |  (+)-Usnic acid  |  hSMG-1 inhibitor 11j  |  mTOR inhibitor-1  |  TMBIM6 antagonist-1  |  Hederacolchiside A1  |  NSC781406

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