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BD-1047 dihydrobromide

CAS No. : 138356-21-5

MCE 站：BD-1047 dihydrobromide

产品活性：BD-1047 二氢溴酸盐是一种选择性的 sigma-1 receptor 受体拮抗剂，作用于精神分裂症动物模型，具有抗精神病活性。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Sigma Receptor

In Vitro: BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.

In Vivo: BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice.
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine).
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  PRE-084 hydrochloride  |  Dimemorfan phosphate  |  Siramesine hydrochloride  |  Cutamesine dihydrochloride  |  Blarcamesine hydrochloride  |  Glycerol phenylbutyrate  |  BD1063 dhydrochloride  |  SR-31747  |  Sigma-2 receptor antagonist 1  |  Blonanserin  |  Roluperidone  |  Ditolylguanidine  |  OPC-14523 hydrochloride  |  Panamesine  |  4-IBP  |  DuP 734  |  E1R  |  KB-5492 anhydrous  |  PD 144418  |  (±)-Vesamicol hydrochloride

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