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产品价格:电议      采购度:1600      原产地:美洲
发布时间:2021/7/29 22:46:22 所属地区:上海 上海市
简要描述:
Diazoxide (Sch-6783) 是一种 ATP 敏感性的钾离子通道 (potassium channel) 激活剂,有潜力用于高胰岛素血症的研究。
标签:Proglycem
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CAS No. : 364-98-7
MCE 站:Diazoxide
产品活性:Diazoxide (Sch-6783) 是一种 ATP 敏感性的钾离子通道 (potassium channel) 激活剂,有潜力用于高胰岛素血症的研究。
研究领域:Membrane Transporter/Ion Channel | Autophagy
作用靶点:Potassium Channel | Autophagy
In Vitro: Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia.
Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage.
In Vivo: Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels.
Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | FDA-Approved Drug Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Nigericin sodium salt | BAPTA-AM | Rosuvastatin Calcium | SKF-96365 hydrochloride | Glibenclamide | SCH-23390 hydrochloride | Tetrandrine | Amiodarone hydrochloride | TRAM-34 | Ifenprodil tartrate | Minoxidil | 20(S)-Ginsenoside Rg3 | Senicapoc | Tannic acid | DCPIB | Astemizole | Ketanserin | Quinine | E-4031 | Terfenadine | Hydrochlorothiazide | GW9508 | Daurisoline | Nicorandil | Dofetilide | Pinacidil monohydrate | ML277 | Tolbutamide | Almitrine mesylate | Flufenamic acid
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更新时间:2024/1/2 10:17:17
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