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Cefamandole nafate

CAS No. : 42540-40-9

MCE 站：Cefamandole nafate

产品活性：Cefamandole nafate (Cefamandole formate sodium) 是第二代广谱头孢菌素抗生素。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.

In Vivo: The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month.
After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.

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