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ZM39923 hydrochloride

CAS No. : 1021868-92-7

MCE 站：ZM39923 hydrochloride

产品活性：ZM39923 hydrochloride 是一种 JAK3 抑制剂， pIC₅₀ 值为 7.1；ZM39923 hydrochloride 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC₅₀ 值为 10 nM。

研究领域：Epigenetics  |  Stem Cell/Wnt  |  JAK/STAT Signaling

作用靶点：JAK

In Vitro: ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC₅₀ of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC₅₀, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC₅₀ <5.0). ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC₅₀ of 10 nM, and acts directly on purified TGM2 to inhibit the Ca²⁺ activated form of TGM2. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells.

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