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TAS-301

CAS No. : 193620-69-8

MCE 站：TAS-301

产品活性：TAS-301 是一种平滑肌迁移和增殖抑制剂，能够抑制 PDGF 诱导的 PKC 的活化。

研究领域：Epigenetics  |  TGF-beta/Smad

作用靶点：PKC

In Vitro: TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca²⁺ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM.

In Vivo: TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.

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