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FIIN-2

CAS No. : 1633044-56-0

MCE 站：FIIN-2

产品活性：FIIN-2 是 FGFR 的不可逆抑制剂，对FGFR1，FGFR2，FGFR3和FGFR4的IC₅₀ 值分别为3.1，4.3，27和45 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FGFR

In Vitro: FIIN-2 potently inhibits WT FGFRs (EC₅₀s in the 1- to 93-nM range) and the gatekeeper mutant of FGFR2 (EC₅₀ of 58 nM). FIIN-2 also moderately inhibits EGFR, with an IC₅₀ of 204 nM. FIIN-2 inhibits proliferation of FGFR1-4 Ba/F3 cells with EC₅₀s in the single- to double-digit nanomolar range and are especially potent against FGFR2, with EC₅₀s in the 1-nM range. FIIN-2 shows good potency against gatekeeper mutant V564F.

In Vivo: Treatment of fish in the embryonic state with either FIIN-2 causes defects to the posterior mesoderm similar to the phenotypes reported following genetic knockdown of FGFR or treatment with other reported FGFR inhibitors. FIIN-2 causes mild or severe phenotypes to the tail morphogenesis in all treated embryonic zebrafish.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Covalent Screening Library  |  Reprogramming Compound Library  |  Anti-Lung Cancer Compound Library  |  SU 5402  |  Heparan Sulfate  |  PD173074  |  Formononetin  |  Gandotinib  |  KW-2449  |  Ferulic acid  |  PD-166866  |  CP-547632  |  PP58  |  SUN11602  |  R1530  |  2,5-Dihydroxybenzoic acid  |  Tyrosine kinase-IN-1  |  PD-161570  |  ARQ 069  |  PD-089828  |  SM1-71  |  SU4984

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