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SKF 38393 hydrochloride

CAS No. : 62717-42-4

MCE 站：SKF 38393 hydrochloride

产品活性：SKF 38393 hydrochloride 是一种多巴胺 D1 受体 (dopamine D1 receptor) 的选择性激动剂, IC₅₀ 值为 110 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vitro: SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP.
SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.

In Vivo: SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione.
SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine.
SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline.
SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action.

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