MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BMS-5

CAS No. : 1338247-35-0

MCE 站：BMS-5

产品活性：BMS-5 (LIMKi 3) 是一种高效的 LIMK 抑制剂，抑制 LIMK1 和 LIMK2，IC₅₀ 分别为 7 nM 和 8 nM。

研究领域：Cell Cycle/DNA Damage

作用靶点：LIM Kinase (LIMK)

In Vitro: BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2^ΔEx2 mouse Schwann cells (MSCs) with an IC₅₀ of ~2 ?M. BMS-5 (LIMKi 3) reduces Nf2^ΔEx2 MSC viability in a dose-dependent manner with an IC₅₀ of 3.9 ?M, but does not significantly reduce the viability of control Nf2^flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 ?M BMS-5, Nf2^ΔEx2 MSC viability is 40% compared to 83% for controls.

In Vivo: BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  BMS-3  |  T56-LIMKi  |  TH-257  |  R-10015  |  SM1-71  |  SR7826

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。