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SRI-011381 hydrochloride

CAS No. : 2070014-88-7

MCE 站：SRI-011381 hydrochloride

产品活性：SRI-011381 hydrochloride 是有口服生物活性的 TGF-beta 信号通路的激活剂，具有神经保护作用。

研究领域：Stem Cell/Wnt  |  TGF-beta/Smad

作用靶点：TGF-beta/Smad

In Vitro: SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.

In Vivo: SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.
SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.
SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.
SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.
SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.

相关产品：Bioactive Compound Library Plus  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Neuroprotective Compound Library  |  Pirfenidone  |  (E)-SIS3  |  Kartogenin  |  Asiaticoside  |  Halofuginone  |  Oxymatrine  |  Hydrochlorothiazide  |  Disitertide  |  Alantolactone  |  Trimethylamine N-oxide  |  Chebulinic acid  |  Butaprost  |  10,11-Dehydrocurvularin

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