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BEC hydrochloride

CAS No. : 222638-67-7

MCE 站：BEC hydrochloride

产品活性：BEC hydrochloride 是一种缓慢结合的竞争性精氨酸酶 II ( Arginase II) 抑制剂，在 pH 7.5 和 pH 9.5 时 K_i 值分别为 0.31 μM 和 30 nM。

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：Arginase

In Vitro: The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 ? resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction.

In Vivo: Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Covalent Screening Library  |  Arginase inhibitor 1  |  nor-NOHA acetate  |  Piceatannol 3'-O-glucoside  |  DL-Norvaline  |  2-Aminoimidazole

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