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CCG215022

CAS No. : 1813527-81-9

MCE 站：CCG215022

产品活性：CCG215022 是一种G蛋白偶联受体激酶 (GRK) 抑制剂，作用于 GRK2，GRK5 和 GRK1，IC₅₀ 分别为 0.15±0.07 μM，0.38±0.06 μM 和 3.9±1 μM。

研究领域：Protein Tyrosine Kinase/RTK  |  Stem Cell/Wnt

作用靶点：PKA

In Vitro: CCG215022 has nanomolar potency against both GRK2 and GRK5 and is at least 20-fold more potent than Paroxetine. In the course of a GRK2 structure-based drug design campaign, CCG215022 exhibits nanomolar IC₅₀ values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. Treatment of murine cardiomyocytes with CCG215022 results in significantly increases contractility at 20-fold lower concentrations than Paroxetine, an inhibitor with more modest selectivity for GRK2.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Staurosporine  |  H-89 dihydrochloride  |  Bucladesine sodium  |  8-Bromo-cAMP sodium salt  |  Fasudil Hydrochloride  |  K-252a  |  Metadoxine  |  Daphnetin  |  HA-100  |  KT5720  |  Gliotoxin  |  PKA Inhibitor Fragment (6-22) amide TFA  |  KT5823  |  PKI(5-24)  |  AT7867 dihydrochloride  |  Kemptide  |  PKI 14-22 amide,myristoylated TFA  |  Rp-cAMPS triethylammonium salt  |  Sp-cAMPS  |  A-3 hydrochloride  |  Bilobetin  |  Jaspamycin  |  Malantide  |  UCN-02  |  Warangalone

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