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Oxantel pamoate

CAS No. : 68813-55-8

MCE 站：Oxantel pamoate

产品活性：Oxantel pamoate 是一种广泛使用的驱虫剂，有效针对Trichuris muris 和钩虫。

研究领域：Anti-infection

作用靶点：Parasite

In Vivo: The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED₅₀s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED₅₀s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Chloroquine  |  Hydroxychloroquine sulfate  |  Ivermectin  |  Kaempferol  |  Metronidazole  |  Dihydroartemisinin  |  Niclosamide  |  Suramin sodium salt  |  Artesunate  |  Artemisinin  |  Quinidine  |  Halofuginone  |  Miransertib  |  Mefloquine hydrochloride  |  Quinacrine dihydrochloride  |  Sanguinarine chloride  |  Amodiaquine dihydrochloride dihydrate  |  Ascomycin  |  Mebendazole  |  Atovaquone  |  Methylene Blue  |  Bithionol  |  Diminazene aceturate  |  Okadaic acid  |  Quinine  |  Urethane  |  Levamisole hydrochloride  |  Osthole  |  Fenbendazole

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