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Procyclidine hydrochloride

CAS No. : 1508-76-5

MCE 站：Procyclidine hydrochloride

产品活性：Procyclidine hydrochloride 是一种有效的抗胆碱能试剂，也具有NMDA拮抗剂的特性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vivo: Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain.

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