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Norverapamil hydrochloride

CAS No. : 67812-42-4

MCE 站：Norverapamil hydrochloride

产品活性：Norverapamil hydrochloride，是 Verapamil 的 N-去甲基代谢物，是一种钙通道 (L-type calcium channel) 阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：Calcium Channel  |  P-glycoprotein  |  Drug Metabolite

In Vitro: Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil.
Verapamil and its major metabolite norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.

In Vivo: Norverapamil hydrochloride (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively.

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Neuroprotective Compound Library  |  Clozapine N-oxide  |  Ionomycin  |  L-Ascorbic acid  |  Thapsigargin  |  Verapamil hydrochloride  |  Oseltamivir acid  |  Ebselen  |  Nifedipine  |  Fasudil Hydrochloride  |  2-Aminoethyl diphenylborinate  |  Elacridar  |  Acetylcholine chloride  |  GSK1016790A  |  Urolithin A  |  Tetrandrine  |  Tariquidar  |  Mibefradil dihydrochloride  |  CDN1163  |  Nimodipine  |  Gabapentin  |  L-Phenylalanine  |  Penfluridol  |  Valspodar  |  Atazanavir sulfate  |  Risperidone  |  Diltiazem hydrochloride  |  Istaroxime hydrochloride  |  Cromolyn sodium

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