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NOD-IN-1

CAS No. : 132819-92-2

MCE 站：NOD-IN-1

产品活性：NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂，IC₅₀ 值分别为 5.74 μM 和 6.45 μM。

研究领域：Immunology/Inflammation

作用靶点：NOD-like Receptor (NLR)

In Vitro: NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC₅₀ (NOD1)=5.74 μM; IC₅₀ (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.

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