MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Rivastigmine

CAS No. : 123441-03-2

MCE 站：Rivastigmine

产品活性：Rivastigmine (S-Rivastigmine) 是一种具有口服活性的，有效的胆碱酯酶 (ChE) 抑制剂，可抑制丁酰胆碱酯酶 (BChE) 和乙酰胆碱酯酶 (AChE)，IC₅₀ 分别为 0.037 μM 和 4.15 μM。Rivastigmine 可透过血脑屏障 (BBB)。Rivastigmine 是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。

研究领域：Neuronal Signaling

作用靶点：AChE

In Vitro: Rivastigmine (S-Rivastigmine; 1 ?M; 24 hours) reduces LPS (2.5 ?g/ml)-induced TNF-α and IL-6 by 50% and 46% combined with carbachol (10 ?M), respectively and does not cause any significant reduction in pro-inflammatory cytokines .
Rivastigmine (1 ?M), carbachol (10 ?M), or a combination of both drugs, does not have a cytotoxic effect on activated cells.

In Vivo: Rivastigmine (S-Rivastigmine; 0.5-2.5 mg/kg; IP; 60 min before the tests) significantly and dose-dependently improved the behavioral impairments caused by Aluminum (HY-B1521).
Rivastigmine (0.5, 1 mg/kg/day; s.c; for 8 days) reduces by about 50% and 60% respectively, the concentration of IL-6 but not those of TNF-α and IL-1β in BALB/c OlaHsd male mice aged 8-9 weeks weighing 200–250 g with acute colitis.
Rivastigmine (1 mg/kg), but not (0.5 mg/kg), partially antagonized colon shrinkage and completely prevented bleeding. Treatment with rivastigmine (0.5 mg/kg) causes little change in these pathological manifestations, but rivastigmine (1 mg/kg) causes a partial restoration of the structure of the crypts and a reduction in sub-mucosal edema and cell infiltration. Rivastigmine (1 mg/kg) causes a 4.7% reduction in body weight at the end of the experiment.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  CNS-Penetrant Compound Library  |  Drug Repurposing Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer’s Disease Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Donepezil Hydrochloride  |  Garcinol  |  sn-Glycero-3-phosphocholine  |  Galanthamine  |  Coumaran  |  Protriptyline hydrochloride  |  Pyridostigmine bromide  |  Scopoletin  |  Imperatorin  |  Sinapine thiocyanate  |  (-)-Huperzine A  |  Timosaponin AIII  |  Aldicarb sulfone  |  Phenserine  |  α-NETA  |  β-NETA  |  (±)-Huperzine A  |  4-Methylbenzylidene camphor  |  Acetylshikonin  |  Corynoline  |  Demecarium Bromide  |  Jatrorrhizine chloride  |  Rhodiosin  |  Tacrine hydrochloride (hydrate)  |  Corydaline  |  Edrophonium chloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。