型号:
产品价格:电议      采购度:1619      原产地:美洲
发布时间:2021/8/2 15:30:44 所属地区:上海 上海市
简要描述:
Encequidar (HM30181; HM30181A) 是一种有效的选择性的P-glycoprotein抑制剂。
标签:HM30181
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 849675-66-7
MCE 站:Encequidar
产品活性:Encequidar (HM30181; HM30181A) 是一种有效的选择性的P-glycoprotein抑制剂。
研究领域:Membrane Transporter/Ion Channel
作用靶点:P-glycoprotein
In Vitro: Encequidar (HM30181; HM30181A) is shown to be approximately equipotent with the reference Pgp inhibitor tariquidar in inhibiting rhodamine 123 efflux from CCRF-CEM T cells (IC50, tariquidar: 8.2±2.0 nM, Encequidar (HM30181): 13.1±2.3 nM) . Encequidar (HM30181) shows a high selectivity for mP-gp and its potency is 20-50 times higher than that of tariquitar, another third generation P-gp inhibitor.
In Vivo: PET scans with the Pgp substrate (R)-[11C]NSC 657799 in FVB wild-type mice pretreated i.v. with Encequidar (HM30181) (10 or 21 mg/kg) failes to show significant increases in (R)-[11C]NSC 657799 brain uptake compared with vehicle treated animals. Encequidar (HM30181) inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. Encequidar (HM30181) increases the oral bioavailability of co-administered NSC 125973 by more than 12 times in rats.
相关产品:Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Clinical Compound Library | Verapamil hydrochloride | Elacridar | Tariquidar | Valspodar | Atazanavir sulfate | Risperidone | Zosuquidar trihydrochloride | Selamectin | Piperine | (20S)-Protopanaxadiol | Sinapine thiocyanate | Solamargine | Dofequidar fumarate | Paris saponin VII | (R)-Verapamil hydrochloride | Chrysosplenetin | Coniferyl ferulate | Hypophyllanthin | Isosinensetin | CP-100356 hydrochloride | Norverapamil hydrochloride | NSC23925 | Phellamurin
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:17:29
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品