型号:
产品价格:电议      采购度:1602      原产地:美洲
发布时间:2021/8/2 15:38:26 所属地区:上海 上海市
简要描述:
Osalmid是核糖核苷酸还原酶小亚基M2(RRM2)的靶向化合物; μM。
标签:Oxaphenamide
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 526-18-1
MCE 站:Osalmid
产品活性:Osalmid是核糖核苷酸还原酶小亚基M2(RRM2)的靶向化合物;抑制核糖核苷酸还原酶活性的IC50值为8.23 μM。
研究领域:Anti-infection
作用靶点:HBV
In Vitro: Osalmid is identified as a potential ribonucleotide reductase small subunit M2 (RRM2) compound. Osalmid is 10-fold more active in inhibiting ribonucleotide reductase (RR) activity than hydroxyurea, and significantly inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells in a time- and dose-dependent manner. After treatment for 8 days with Osalmid, the EC50 for HBV DNA inhibition are 11.1 μM for culture supernatant and 16.5 μM for cells. Osalmid suppresses RR activity in a concentration-dependent manner, with an IC50 of 8.23 μM. Osalmid is shown to possess potent activity against a 3TC-resistant HBV strain, suggesting utility in treating drug-resistant HBV infections.
In Vivo: Osalmid reduces RR activity and HBV replication in HBV-transgenic mice and shows a synergistic efficacy with 3TC without significant toxicity. Oral dosing of osalmid at 400 mg/kg/d results in a time-dependent inhibition of HBV DNA replication. After treatment for 4 weeks, osalmid suppresses HBV DNA replication by about 40-45% as compared to the control in mouse sera and liver tissues.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | FDA-Approved Drug Library | Antiviral Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | FDA Approved & Pharmacopeial Drug Library | Doxorubicin hydrochloride | OSS_128167 | Entecavir monohydrate | Tenofovir | Merimepodib | Osthole | 4,5-Dicaffeoylquinic acid | Punicalagin | Adefovir dipivoxil | Telbivudine | Isochlorogenic acid A | Oxethazaine | Adefovir | Bicyclol | Catalpol | Bay 41-4109 | Clevudine | Squalamine | Tenofovir Disoproxil | Pseudolaric Acid B | Thiamine hydrochloride | Cetylpyridinium chloride | Bifendate | Punicalin | RO8191 | Taribavirin hydrochloride | Alisol F | 4-Hydroxyacetophenone
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:17:29
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品