MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Thiomyristoyl

CAS No. : 1429749-41-6

MCE 站：Thiomyristoyl

产品活性：Thiomyristoyl是高效特异性的SIRT2抑制剂，IC₅₀值为28 nM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Sirtuin

In Vitro: Thiomyristoyl (TM) is a potent SIRT2-specific inhibitor with broad anticancer activity but little effect on non-cancerous cells. SIRT2-inhibition promotes c-Myc ubiquitination and degradation, suggesting the therapeutic potential of TM to target certain c-Myc-driven cancers. TM could inhibit SIRT2 with an IC₅₀ of 28 nM, but inhibits SIRT1 with an IC₅₀ value of 98 μM and does not inhibit SIRT3 even at 200 μM. TM inhibits three human breast cancer cell lines, MCF-7, MDA-MB-468, and MDA-MB-231.

In Vivo: TM inhibits tumor growth in mouse models of breast cancer. TM does not cause significant toxicity in mice and no significant weight loss is observed in TM-treated mice. S5H, the acetyl-a-tubulin level is moderately but statistically significantly increased in tumors from TM-treated mice compared with those from vehicle-treated mice, suggesting that TM indeed inhibits SIRT2 in vivo.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Resveratrol  |  Selisistat  |  Nicotinamide  |  Nicotinamide riboside chloride  |  3-TYP  |  Suramin sodium salt  |  OSS_128167  |  Fisetin  |  UBCS039  |  Sirtinol  |  CAY10602  |  AGK2  |  AK-7  |  SIRT5 inhibitor 1  |  Cambinol  |  MC3482  |  Ganoderic acid D  |  PROTAC Sirt2 Degrader-1  |  SRT 2183  |  Dihydrocoumarin  |  Ginkgolide C  |  Inauhzin  |  SIRT-IN-3  |  JFD00244  |  Gardenia yellow  |  Agrimol B  |  Sirtuin modulator 1  |  Ophiopogonin D'  |  Scopolin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。