型号:
产品价格:电议      采购度:1600      原产地:美洲
发布时间:2021/8/2 15:47:25 所属地区:上海 上海市
简要描述:
Farampator (CX-691;Org24448) 是一种AMPA受体正调节剂。
标签:CX-691
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CAS No. : 211735-76-1
MCE 站:Farampator
产品活性:Farampator (CX-691;Org24448) 是一种AMPA受体正调节剂。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:iGluR
In Vivo: Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.). Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs.
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更新时间:2024/1/2 10:17:29
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