MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Elacestrant dihydrochloride

CAS No. : 1349723-93-8

MCE 站：Elacestrant dihydrochloride

产品活性：Elacestrant dihydrochloride (RAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD)，对 ERα 和 ERβ 的IC₅₀ 值分别为 48 和 870 nM。

研究领域：Others

作用靶点：Estrogen Receptor/ERR

In Vitro: RAD1901 selectively binds to and degrades the ER and is a potent antagonist of ER-positive breast cancer cell proliferation. RAD1901 treatment exhibits dose-dependent inhibition of ERα expression, with an EC₅₀ of 0.6 nM. Treatment of ER-positive MCF-7 cells with E2 results in a potent and dose-dependent increase in proliferation, with an EC₅₀ of 4 pM. Treatment of cells with RAD1901 in the presence of 10 pM E2 resultsin a dose-dependent decrease in proliferation, with an IC₅₀ value of 4.2 nM.

In Vivo: RAD1901 produces a robust and profound inhibition of tumor growth in MCF-7 xenograft models. RAD1901-treated animals survived longer than those treated with either control or ICI 182780. RAD1901 preserves ovariectomy-induced bone loss and preventes the uterotropic effects of E2.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Tamoxifen  |  Fulvestrant  |  Estradiol  |  4-Hydroxytamoxifen  |  Kaempferol  |  G15  |  G-1  |  Cholesterol  |  Bazedoxifene acetate  |  PHTPP  |  Raloxifene hydrochloride  |  DPN  |  Estrone  |  Chrysin  |  (-)-(S)-Equol  |  27-Hydroxycholesterol  |  Liquiritigenin  |  Propyl pyrazole triol  |  Toremifene citrate  |  Genistin  |  Diethylstilbestrol  |  Saikosaponin D  |  Lasofoxifene Tartrate  |  (20S)-Protopanaxatriol  |  Estriol  |  Prinaberel  |  Clomiphene citrate  |  Kaempferide

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。