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Fesoterodine fumarate

CAS No. : 286930-03-8

MCE 站：Fesoterodine fumarate

产品活性：Fesoterodine Fumarate 是一种口服有效，非亚型选择性的，竞争性毒蕈碱受体 (mAChR) 拮抗剂，对 M1，M2，M3，M4，M5 受体的 pK_i 值分别为 8.0，7.7，7.4，7.3，7.5。Fesoterodine Fumarate 用于膀胱过度活动症 (OAB)。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: FFesoterodine Fumarate decreases micturition frequency, urgency severity and urgency incontinence episodes and increases the volume voided with each micturition.
After oral administration, Fesoterodine Fumarate is rapidly and extensively hydrolysed in plasma by nonspecific esterases to Desfesoterodine (5-hydroxymethyl tolterodine; SPM 7605; HY-76569; an active metabolite of Fesoterodine).

In Vivo: Fesoterodine Fumarate (0.01-1 mg/kg; IV) reduces the micturition pressure and increases bladder capacity and ICIs (intercontraction intervas) at the lowest dose tested of 0.01 mg/kg.

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